Metastatic inefficiency in mice bearing B16 melanomas
نویسندگان
چکیده
منابع مشابه
Apoptosis: an early event in metastatic inefficiency.
Whereas large numbers of cells from a primary tumor may gain access to the circulation, few of them will give rise to metastases. The mechanism of elimination of these tumor cells, often termed "metastatic inefficiency," is poorly understood. In this study, we show that apoptosis in the lungs within 1-2 days of introduction of the cells is an important component of metastatic inefficiency. Firs...
متن کاملInterstitial Hypertension in Superficial Metastatic Melanomas in
Since 1950, several investigators have demonstrated that interstitial hypertension is a pathophysiological characteristic of experimental solid tumors. To date, interstitial fluid pressure (IFF) has not been measured in human tumors in situ. In this study we measured with the nick-inneedle technique the interstitial fluid pressure in superficial melanoma métastases(n = 12) in patients (n = 10)...
متن کاملBody distribution of free, liposomal and nanoparticle-associated mitoxantrone in B16-melanoma-bearing mice.
B16-melanoma-bearing mice were treated with four different formulations containing equivalent doses of the highly effective antineoplastic drug mitoxantrone. The formulations were: A mitoxantrone solution, a negatively charged liposome preparation (small unilamellar vesicles), a 14C-labeled polybutylcyanoacrylate- (PBCA) nanoparticle suspension, and a suspension of poloxamine 1508-coated 14C-PB...
متن کاملEfficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
Previously, we reported that acetaminophen (APAP) showed selective toxicity towards melanoma cell lines. In the current study, we investigated further the role of tyrosinase in APAP toxicity in SK-MEL-28 melanoma cells in the presence of a short hairpin RNA (shRNA) plasmid, silencing tyrosinase gene. Results from tyrosinase shRNA experiments showed that APAP led to negligible toxicity in shRNA ...
متن کاملLack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice.
Foxp3 Tregs are essential for maintaining immune tolerance in mice and men. Except for expression in a minor population of CD8 T cells,1 Foxp3 is currently believed to be restricted to CD4 Tregs in mice, because widespread nonhematopoietic Foxp3 expression and its putative implication in tolerance have been refuted.2,3 Thus, the employment of Foxp3 reporter mice, including Foxp3DTR-eGFP (DEREG)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1982
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1982.6